Mushrooms and antibiotics

[Mystic Wolf]

Calvacin from giant puffball mushrooms Lycoperdon perlatum
Calvatia gigantea Puff Ball Calvacin antibiotic
Laboratory tests indicate that extracts of the puffball have antimicrobial and antifungal activities.
Armillaric acid from honey mushroom Armillaria mellea they’re also quite medicinal. Research has shown that a water-soluble polysaccharide from the honey mushroom exhibits a potent tumor inhibitory effect on human lung cancer cells (Wu et al., 2012). The mycelia (the fungal “root-like” network) possesses an antibiotic compound, armillaric acid that is effective against gram-positive bacteria and yeast (Obuchi et al., 1990). Honey mushrooms also contain the biologically active compounds tryptamine, L-tryptophan, and serotonin (Muszynska et al., 2011). http://foragingpittsburgh.com/2014/10/21/honey-mushroom-armillaria-...
Campestrin from meadow mushrooms Agaricus campestris Campestrin antibiotic
Coprinol from inky caps Coprinus species
Ganomycin from reishi mushrooms Ganoderma lucidum antibiotic
Sorolin from turkey tail mushrooms Trametes versicolor antibiotic
Agaricin from agarikon mushrooms Fomitopsis officinalis https://books.google.com/books?id=qtsTH7ekvVYC&pg=PT115&lpg...
Nutrient-rich mushrooms, before sporulation, resist infection and rot, and I believe each mushroom species predetermines which bacterial colonies can live upon it. How do mushrooms do this? The cell surface of mycelium "sweats" out antibiotics and many mushrooms target specific species of bacteria.
So far researchers have found that mushrooms contain polysaccharides, glycoproteins, protoglycans, ergosterols, triterpenoids, enzymes, acids, and antibiotics that when used individually and in concert can stop infection. Scientists have also found that each species of mushroom has a signature architecture and defense against microbes. (Learn more about the medicinal properties of specific mushrooms in my book MycoMedicinals). http://www.shareguide.com/mushrooms.html
Mushrooms having both antiviral and antibacterial properties may prevent such opportunistic infections. Mushrooms also influence populations of bacteriophages--viruses that use bacteria as incubators and vectors for further infection
Several mushroom species--oyster, shiitake, maitake, turkey tail, and others--have shown anti-HIV activity under certain circumstances. Protease inhibitors, commonly prescribed to combat HIV, interfere with lipid metabolism in the liver, causing an accumulation of "bad" cholesterol (LDL). Oyster mushrooms contain a natural isomer of lovastatin, an FDA-approved cholesterol-lowering drug.
Coprinus comatus Shaggy mane Coprinol antibiotic
Sparassiscrispa Cauliflower mushroom antibiotic (sparassol)
https://books.google.com/books?id=NPI8_-omzvsC&pg=PA44&lpg=...

[Minque Paw]

Thank you Don!